Psychological intervention has always been part of our efforts to save lives. At present, the coronavirus disease (COVID-19) is spreading fast across the world with multiple epicenters. In the face of this common challenge for mankind, all countries should watch out for and help one another. As a responsible big country, China actively supports and participates in international cooperation to combat the epidemic, makes its contribution to regional and international public health security, and promotes the building of a community with a shared future for mankind. In addition to offering advice on protection against the virus and treatment of the disease, China would also like to share its experience in psychological intervention. When the outbreak evolves to a level that it threatens people’s lives, fear, anxiety and panic will grow and spread, and the psychological defense of many people may be damaged, adding to the harm caused by the epidemic. This handbook aims to help the public reduce mental stress, improve their psychological defense, and build confidence in defeating the epidemic.